Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 19, Issue 21, Pages 4685-4690Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ob00494h
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Funding
- DST [SR/S2/JCB-17/2008, DST/INSPIRE/04/2016001704]
- SERB [CRG/2018/000552]
- Indian Institute of Science Education and Research (IISER), Bhopal
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The exo-selective asymmetric 1,3-dipolar cycloaddition reaction catalyzed by (R)-DM-BINAP/Cu(CH3CN)(4)BF4 complex has led to the synthesis of highly functionalized pyrrolidines with multiple stereogenic centers. The products exhibited good yields, diastereoselectivities, and excellent enantioselectivities, with up to 99% ee.
An (R)-DM-BINAP/Cu(CH3CN)(4)BF4 complex catalyzed exo-selective asymmetric 1,3-dipolar cycloaddition (1,3-DCA) reaction of imino esters with alpha,beta-unsaturated pyrazoleamides has been developed. A series of highly functionalized pyrrolidines with multiple stereogenic centers were obtained with good yields and diastereoselectivities and excellent enantioselectivities (up to 99% ee).
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