Journal
FITOTERAPIA
Volume 122, Issue -, Pages 85-89Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2017.08.013
Keywords
Sundarban Mangrove; Xylocarpus granaaan; Limonoid; Structure elucidation; Anti-ERT
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Funding
- National Natural Science Foundation of China [U1501221, 31770377, 81661148049, 81125022]
- Pearl River S &T Nova Program of Guangzhou, P.R. China [201506010023]
- Science and Technology Planning Project of Guangdong Province, P.R. China [2013B051000057]
- Special Financial Fund of Innovative Development of Marine Economic Demonstration Project, P.R. China [GD2012-D01-001]
- Discovering Antimalarials from Marine Organisms, Department of Biotechnology, Government of India [BT/PR12653/AAQ/03/472/2009]
- Indian National Science Academy Visiting Fellowship
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Five new limonoids, named sundarbanxylogranins A-E (1-5), were isolated from the seeds of an Indian mangrove, Xylocarpus granatum, collected from mangrove swamps of the Sundarbans, India. The structures of these limonoids were established by HRESIMS and NMR spectroscopic data. Sundarbanxylogranin A (1) is a rare limonoid containing a bicyclo[5.2.1]dec-3-en-8-one scaffold as the ring A/B-fused core; whereas sundarbanxylogranin B (2) is a typical mexicanolide with an 8 alpha, 30 alpha-epoxy ring. Sundarbanxylogranins C-E (3-5), among which the former two possess a 29-OMe group with different orientation, belong to a small group of limonoids containing a C-1-O-C-29 oxygen bridge. Sundarbarnrylogranin B exhibited moderate anti-HIV activity with an IC50 value of 23.14 +/- 1.29 mu M and a CC50 value of 78.45 +/- 1.69 mu M, respectively.
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