Journal
FITOTERAPIA
Volume 121, Issue -, Pages 152-158Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2017.07.009
Keywords
Lignan glycosides; Alangium kurzii; Antibacterial activities
Categories
Funding
- Professor of Chang Jiang Scholars Program, NSFC [81230090, 81520108030, 1302658]
- Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products [16DZ2280200]
- Scientific Foundation of Shanghai China [12401900801, 12401900501, 13401900103, 13401900101]
- National Major Project of China [2011ZX09307-002-03]
- National Key Technology R & D Program of China [2012BAI29B06]
- State Key Laboratory of Innovative Natural Medicine and TCM Injections
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Seven new lignan glycosides (1-3, 8-10, and 14) and 17 known compounds were isolated from the branches of Alangium kurzii Craib var. laxifolium. Their structures were established by spectroscopic analysis and circular dichroism (CD) and X-ray analysis. The isolated compounds were evaluated for their antibacterial activities against Staphylococcus aureus CI1011, Streptococcus suis CI1608, Salmonella gallinarum CI0912, Enterococcus faecalis Cl1304, Aeromonas hydrophila CI1008, Escherichia coil CI151012, Vibrio parahaemoiyticus CI150506, Klebsiella pneumoniae CI131216, Pseudomonas aeruginosa CI1011, Staphylococcus epidermidis CI1110, and Streptococcus agalactiae CI1302. Their minimum inhibitory concentrations (MICs) were determined by serial dilution in 96-well culture plates.
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