Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 19, Issue 20, Pages 4429-4459Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ob00472g
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Funding
- Russian Science Foundation [20-73-10077]
- Russian Science Foundation [20-73-10077] Funding Source: Russian Science Foundation
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This review summarizes the recent advances in the functionalization of polyfluoro(aza)aromatics through both transition metal-catalyzed and metal-free C-C coupling reactions. Mechanistic features for chemical transformations of fluoroarene scaffolds and new opportunities for practical applications of designed fluorinated molecules have been highlighted.
Polyfluoro(aza)aromatic compounds are of interest in various fields of practical applications, such as medicinal and agrochemistry, materials science and advanced technologies. The C-C coupling reactions are known to be a promising synthetic tool to create challenging fluorinated molecules of diverse architectures. In this review, we have summarized the recent advances in the functionalization of polyfluoro(aza)aromatics via both transition metal-catalyzed and metal-free C-C coupling reactions for the period from 2006 to the beginning of 2021. Also, mechanistic features for chemical transformations of fluoroarene scaffolds and new opportunities for practical applications of the designed fluorinated molecules have been highlighted.
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