Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 46, Pages 5646-5649Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc00314c
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Funding
- National Natural Science Foundation of China [21927811, 21874086]
- National Key R&D Program of China [2019YFA0210100]
- Youth Innovation Science and Technology Program of Higher Education Institution of Shandong Province [2019KJC022]
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A polydopamine core-shell nanoplatform engineered with a covalent organic framework (COF) was developed, benefiting from the ultrasmall pores and abundant functional sites of COF. The nanoplatform exhibited enhanced drug loading capacity and reduced drug leakage effect, enabling multimodal imaging-guided photothermal chemo-synergistic tumor-targeted therapy after rational functionalization. This work contributes to the development of COF-based multifunctional theranostic systems.
A covalent organic framework (COF)-engineered polydopamine core-shell nanoplatform (PDA@COF) was developed. The ultrasmall pores and abundant functional sites of the COF endowed the nanoplatform with enhanced drug loading capacity and diminished drug leakage effect. Multimodal imaging-guided photothermal chemo-synergistic tumor-targeted therapy was realized after rational functionalization. This work offers new insights for developing COF-based multifunctional theranostic systems.
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