Journal
DRUG DELIVERY
Volume 28, Issue 1, Pages 884-893Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10717544.2021.1912210
Keywords
hUCMSCs derived exosome; genipin crosslinked hydrogel; skin tissue regeneration; wound healing; rat model
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Funding
- Special Project for the Transformation of Medical Scientific and Technological Achievements
- Key R&D Program of Liaoning Province in 2019-'Applied Study of umbilical Cord Mesenchymal Stem Cells Directed Vascular Endothelial Differentiation in the Treatment of Diabetic Foot'
- Liaoning Province Scientific Research Foundation [20180530017]
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This study utilized a dual-sensitive hydrogel loaded with exosomes derived from hUCMSCs to promote wound healing and skin regeneration, showing significant improvements in wound closure, re-epithelialization rates, and collagen deposition in the wound sites. The results suggest the potential for achieving complete skin regeneration through the use of this novel approach.
Full thickness cutaneous wound therapy and regeneration remains a critical challenge in clinical therapeutics. Recent reports have suggested that mesenchymal stem cells exosomes therapy is a promising technology with great potential to efficiently promote tissue regeneration. Multifunctional hydrogel composed of both synthetic materials and natural materials is an effective carrier for exosomes loading. Herein, we constructed a biodegradable, dual-sensitive hydrogel encapsulated human umbilical cord-mesenchymal stem cells (hUCMSCs) derived exosomes to facilitate wound healing and skin regeneration process. The materials characterization, exosomes identification, and in vivo full-thickness cutaneous wound healing effect of the hydrogels were performed and evaluated. The in vivo results demonstrated the exosomes loaded hydrogel had significantly improved wound closure, re-epithelialization rates, collagen deposition in the wound sites. More skin appendages were observed in exosomes loaded hydrogel treated wound, indicating the potential to achieve complete skin regeneration. This study provides a new access for complete cutaneous wound regeneration via a genipin crosslinked dual-sensitive hydrogel loading hUCMSCs derived exosomes.
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