Neuromyelitis Optica Presenting as Infectious Meningoencephalitis: Case Report and Literature Review

In this patient-focused review, we present a 34-year-old previously healthy man admitted for fever and headache two weeks after a motor vehicle accident. On admission, his workup was concerning for meningoencephalitis based on elevated cerebro-spinal fluid (CSF) white blood cell count and elevated CSF protein. He was admitted for management of meningoencephalitis. During his course, no causative infectious agent was identified despite an extensive workup. He additionally underwent an autoimmune and paraneoplastic workup that was negative. During his hospitalization, he developed acute transverse myelitis manifested by bilateral lower extremity paralysis. After four weeks marked by persistent clinical deterioration, brain biopsy was performed. Pathologic examination was consistent with neuromyelitis optica spectrum disorder (NMOSD). In this case report and literature review, we explore the presentations of NMOSD that mimic an infection. Clinicians should be aware of the possibility of NMOSD masquerading as infectious meningoencephalitis or acute transverse myelitis.

Automated summary

This case discusses a 34-year-old man admitted for fever and headache two weeks after a motor vehicle accident, ultimately diagnosed with neuromyelitis optica spectrum disorder (NMOSD). Despite an extensive workup, no infectious agent was identified, and during treatment, he developed acute transverse myelitis.