Journal
ACS APPLIED BIO MATERIALS
Volume 4, Issue 1, Pages 311-324Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c01364
Keywords
complexity of healing process; hyaluronan; biological materials; regenerative medicine; combination therapy
Funding
- Department of Education of Jilin Province, China [JJKH20190099KJ]
- Outstanding Youth Foundation from the Department of Science and Technology of Jilin Province, China [20170520046JH]
- Fundamental Research Funds for the Central Universities
- National Natural Science Foundation of China [81774240, 81403272]
- China Scholarship Council [201808310047]
- Chenguang Program from Shanghai Education Development Foundation
- Shanghai Municipal Education Commission [15CG48]
- Shanghai Rising-Star Program [17QA1403900]
- Training Plan of Outstanding Young Medical Talents from Shanghai Municipal Health Bureau [2017YQ021]
- Chinese Medicine Association [QNRC2-C14]
- Talents Cultivation Program of Jilin University
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The skin is crucial for protecting the body, detecting environmental changes, and maintaining physiological balance. Hyaluronic acids play key roles in cell differentiation, proliferation, and migration, making them potential candidates for treating skin damage and injury. Advanced strategies are needed for addressing the complexity of the healing process in order to improve treatment outcomes.
The skin can protect the body from external harm, sense environmental changes, and maintain physiological homeostasis. Cutaneous repair and regeneration associated with surgical wounds, acute traumas, and chronic diseases are a central concern of healthcare. Patients may experience the failure of current treatments due to the complexity of the healing process; therefore, emerging strategies are needed. Hyaluronic acids (HAs, also known as hyaluronan), a glycosaminoglycan (GAG) of the extracellular matrix (ECM), play key roles in cell differentiation, proliferation, and migration throughout tissue development and regeneration. Recently, HA derivatives have been developed as regenerative biomaterials for treating skin damage and injury. In this review, the healing process, namely, hemostasis, inflammation, proliferation, and maturation, is described and the role of HAs in the healing process is discussed. This review also provides recent examples in the development of HA derivatives for wound healing.
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