Journal
JNCI CANCER SPECTRUM
Volume 5, Issue 3, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jncics/pkab029
Keywords
-
Categories
Funding
- National Cancer Institute [R03-CA215775-02]
- Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) by National Cancer Institute, National Institutes of Health, US Department of Health and Human Services [U01 CA164930, R01 CA201407]
- NIH/NCI Cancer Center Support Grant [P30 CA015704]
- Agency for Healthcare Research and Quality [T32HS026120]
- National Cancer Institute (NCI), National Institutes of Health (NIH) [U01 CA167551]
- NIH [U01 CA122839, R01 CA143247, U19 CA148107, R01 CA81488]
- Center for Inherited Disease Research (CIDR) - NIH [HHSN268201200008I]
- Instituto de Salud Carlos III
- FEDER funds - a way to build Europe [PI14-613, PI09-1286]
- Agency for Management of University and Research Grants (AGAUR) of the Catalan Government [2017SGR723]
- Junta de Castilla y Leon [LE22A10-2]
- Xarxa de Bancs de Tumors de Catalunya - Pla Director d'Oncologia de Catalunya (XBTC)
- Plataforma Biobancos [PT13/0010/0013]
- German Research Council [BR 1704/6-1, BR 1704/6-3, BR 1704/6-4, CH 117/1-1, HO 5117/2-1, HE 5998/2-1, KL 2354/3-1, RO 2270/8-1, BR 1704/17-1]
- Interdisciplinary Research Program of the National Center for Tumor Diseases (NCT), Germany
- German Federal Ministry of Education and Research [01KH0404, 01ER0814, 01ER0815, 01ER1505A, 01ER1505B]
- DALS: National Institutes of Health [R01 CA48998]
- European Commission (DGSANCO)
- International Agency for Research on Cancer
- Danish Cancer Society (Denmark)
- Ligue Contre le Cancer (France)
- Institut Gustave Roussy (France)
- Mutuelle Generale de l'Education Nationale (France)
- German Cancer Aid (Germany)
- German Cancer Research Center (DKFZ) (Germany)
- Federal Ministry of Education and Research (BMBF) (Germany)
- Deutsche Krebshilfe (Germany)
- Deutsches Krebsforschungszentrum (Germany)
- Federal Ministry of Education and Research (Germany)
- Hellenic Health Foundation (Greece)
- Associazione Italiana per la Ricerca sul Cancro-AIRCItaly (Italy)
- National Research Council (Italy)
- Dutch Ministry of Public Health, Welfare and Sports (VWS) (The Netherlands)
- Netherlands Cancer Registry (NKR) (The Netherlands)
- LK Research Funds (The Netherlands)
- Dutch Prevention Funds (The Netherlands)
- Dutch ZON (Zorg Onderzoek Nederland)
- World Cancer Research Fund (WCRF) (The Netherlands)
- Statistics Netherlands (The Netherlands)
- Nordforsk
- Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway)
- Health Research Fund (FIS) (Spain) [PI13/00061, PI13/01162]
- Regional Government of Andalucia (Spain)
- Regional Government of Asturias (Spain)
- Regional Government of Basque Country (Spain)
- Regional Government of Murcia (Spain)
- Regional Government of Navarra (Spain)
- ISCIII RETIC (Spain) [RD06/0020]
- Swedish Cancer Society (Sweden)
- Swedish Research Council (Sweden)
- County Council of Skane (Sweden)
- County Council of Vasterbotten (Sweden)
- Cancer Research UK (United Kingdom) [14136, C570/A16491, C8221/A19170]
- Medical Research Council (United Kingdom) [1000143, MR/M012190/1]
- Clinical Investigator Award from Damon Runyon Cancer Research Foundation [CI-8]
- NCI [R01CA136726]
- Food Standards Agency
- Cancer Research UK Programme Award [C588/A19167]
- National Institutes of Health, U.S. Department of Health and Human Services [R01 CA81488, U01 CA74783]
- National Institutes of Health [R01 CA66635, P30 DK034987, R01 CA137178, P01 CA087969, UM1 CA186107, R01 CA151993, R35 CA197735, K07CA190673, P50 CA127003]
- Interdisciplinary Health Research Team award from the Canadian Institutes of Health Research [CRT 43821]
- National Cancer Institute of Canada grants [18223, 18226]
- Canadian Cancer Society Research Institute
- National Cancer Institute (NCI) of the National Institutes of Health (NIH) [U01 CA167551, U01/U24 CA074783, U01 CA074794, U24 CA074794, R01 CA076366]
- Canadian Cancer Society CaRE (Cancer Risk Evaluation) program grant
- Ontario Research Fund award [GL201-043]
- Ontario Ministry of Research and Innovation
- ICOBIOBANC - Catalan Institute of Oncology
- Institut National de la Saneetde la Recherche Medicale (INSERM) (France)
- Canadian Institutes of Health Research [112746]
- [ERC-2009-AdG 232997]
Ask authors/readers for more resources
In this large study, several nongenetic risk factors associated with early-onset colorectal cancer were identified, providing a basis for targeted identification of high-risk individuals, which is crucial in mitigating the increasing burden of this disease.
Background: Incidence of early-onset (younger than 50 years of age) colorectal cancer (CRC) is increasing in many countries. Thus, elucidating the role of traditional CRC risk factors in early-onset CRC is a high priority. We sought to determine whether risk factors associated with late-onset CRC were also linked to early-onset CRC and whether association patterns differed by anatomic subsite. Methods: Using data pooled from 13 population-based studies, we studied 3767 CRC cases and 4049 controls aged younger than 50 years and 23 437 CRC cases and 35 311 controls aged 50 years and older. Using multivariable and multinomial logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to assess the association between risk factors and early-onset CRC and by anatomic subsite. Results: Earlyonset CRC was associated with not regularly using nonsteroidal anti-inflammatory drugs (OR = 1.43, 95% CI = 1.21 to 1.68), greater red meat intake (OR = 1.10, 95% CI = 1.04 to 1.16), lower educational attainment (OR = 1.10, 95% CI = 1.04 to 1.16), alcohol abstinence (OR = 1.23, 95% CI = 1.08 to 1.39), and heavier alcohol use (OR = 1.25, 95% CI = 1.04 to 1.50). No factors exhibited a greater excess in early-onset compared with late-onset CRC. Evaluating risks by anatomic subsite, we found that lower total fiber intake was linked more strongly to rectal (OR = 1.30, 95% CI = 1.14 to 1.48) than colon cancer (OR = 1.14, 95% CI = 1.02 to 1.27; P = .04). Conclusion: In this large study, we identified several nongenetic risk factors associated with early-onset CRC, providing a basis for targeted identification of those most at risk, which is imperative in mitigating the rising burden of this disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
