Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 46, Pages 5690-5693Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc02080c
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21772042, 21971066]
- Science and Technology Commission of Shanghai Municipality [18JC1412300]
Ask authors/readers for more resources
In this study, we presented an efficient strategy for the enantioselective synthesis of 2,3-furan-fused carbocycles with three contiguous stereocenters. This transformation is catalyzed by PtCl4/chiral amines through tandem dehydrogenative annulation/Diels-Alder reaction of 2-(1-alkynyl)-2-alken-1-ones and enals, with in situ generation of furan-based ortho-quinodimethane intermediates and iminium activation of enals being crucial to the process.
Herein, we disclosed a highly efficient strategy of enantioselective synthesis of 2,3-furan-fused carbocycles bearing three-contiguous stereocenters. This transformation is catalyzed by dual catalysis of PtCl4/chiral amines via tandem dehydrogenative annulation/Diels-Alder reaction of 2-(1-alkynyl)-2-alken-1-ones and enals. The in situ generation of the furan-based ortho-quinodimethane intermediates and the iminium activation of enals are crucial to this transformation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available