Journal
BIOMATERIALS SCIENCE
Volume 9, Issue 11, Pages 4191-4198Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1bm00569c
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Funding
- National Natural Science Foundation of China (NSFC) [51673100, 21620102005]
- National Key Research and Development Programs of China [2018YFA0209700]
- Tianjin Natural Science Foundation [18JCQNJC03600]
- Fundamental Research Funds for the Central Universities (Nankai University) [ZB19100123, ZB16008705]
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An immunomodulating nano-photosensitizer was developed to enhance reactive oxygen species production and regulate the immunosuppressive tumor microenvironment for improved photoimmunotherapy. Through co-delivery of immunomodulators, this platform showed potential for efficient and precise treatment of tumors.
Photodynamic therapy has great potential for tumor ablation and the activation of antitumor immune responses. However, its overall therapeutic efficiency is often limited by the immunosuppressive tumor microenvironment. We developed a near-infrared light-excitable immunomodulating nano-photosensitizer (NeINP) that can improve reactive oxygen species production and regulate the immunosuppressive TME to improve photoimmunotherapy. The NeINP is composed of a photosensitive core and a pH-responsive polymer shell, which allows for NeINP loading and delivery of small-molecular immunomodulators to tumor sites for regulation of the immunosuppressive TME and effective photoimmunotherapy. Through the co-delivery of celecoxib and the NIR-triggered photodynamic core to tumors, the NeINP was shown to regulate the immunosuppressive TME and enhance antitumor immunity, leading to the elimination of residual tumor and reduction of metastasis and recurrence. The NeINP can be optimized to co-deliver other immunomodulators, and thus has potential as a universal platform for efficient, precise photoimmunotherapy.
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