Journal
FOOD & FUNCTION
Volume 12, Issue 12, Pages 5260-5273Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0fo02100h
Keywords
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Funding
- National Natural Science Foundation of China [32072176, 31271814]
- Fundamental Research Funds for the Central Universities [JZ2019HGTB0065]
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The study demonstrates that Laminaria japonica polysaccharide has a significant effect on inhibiting atherosclerosis and improving insulin resistance induced by high-fat diet in mice, along with reducing obesity, inflammation, metabolic endotoxemia, and gut permeability. Additionally, it can regulate gut microbiota, especially Akkermansia, to achieve these effects.
Insulin resistance has become a worldwide nutrition and metabolic health problem due to the lack of effective protective agents. Laminaria japonica is a well-known marine vegetable. Purified Laminaria japonica polysaccharide (LJP61A) can inhibit atherosclerosis in high-fat-diet (HFD)-fed mice via ameliorating insulin resistance. In this study, we aimed to clarify the mechanism by which LJP61A ameliorates HFD-induced insulin resistance. The results indicated that HFD-induced insulin resistance, obesity, systematic inflammation, metabolic endotoxemia, and gut permeability in mice could be reduced by LJP61A. Gut microbiota analysis showed that the gut microbiota dysbiosis of HFD-fed mice, especially the reduction in mucin-degrading Akkermansia, could be reversed by LJP61A. Additionally, the reduction in mucin-producing goblet cells in HFD-fed mice could also be reversed by LJP61A. Moreover, insulin resistance, obesity, systematic inflammation, metabolic endotoxemia, and gut microbiota dysbiosis in HFD-fed mice could also be alleviated by faecal transplant from LJP61A-treated mice. Overall, LJP61A might be used as a prebiotic to ameliorate HFD-induced insulin resistance and associated metabolic disorders via regulating gut microbiota, especially Akkermansia.
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