Journal
NEW JOURNAL OF CHEMISTRY
Volume 45, Issue 21, Pages 9302-9314Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1nj00704a
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Funding
- National Natural Science Foundation of China [82003585, 21971224]
- Postgraduate Education Reform Project of Henan Province [2019SJGLX008Y, 2019SJGLX034Y]
- Postgraduate Education Reform and Quality Improvement Project of Henan Province [YJS2021AL079]
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This review summarizes recent advances in radical reactions for the direct functionalization of imidazo[1,2-a]pyridines through transition metal catalysis, metal-free oxidation, and photocatalysis strategies.
Imidazo[1,2-a]pyridines are a class of valuable heterocyclic scaffolds in organic synthesis and pharmaceutical chemistry. The direct functionalization of this valuable scaffold has been considered as one of the most efficient strategies for the construction of imidazo[1,2-a]pyridine derivatives. This review summarizes the recent advances in radical reactions for the direct functionalization of imidazo[1,2-a]pyridines through transition metal catalysis, metal-free oxidation, and photocatalysis strategies.
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