Journal
CHEMICAL SCIENCE
Volume 12, Issue 13, Pages 4836-4840Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0sc05883a
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The method involves the use of a copper nucleophile complex as a photocatalyst, which reduces the silicon-tethered aliphatic iodide to an alkyl radical to initiate 1,n-hydrogen atom transfer. Unactivated secondary and tertiary C-H bonds at beta, gamma, and delta positions can be functionalized in a predictable manner.
A method for remote radical C-H alkynylation and amination of diverse aliphatic alcohols has been developed. The reaction features a copper nucleophile complex formed in situ as a photocatalyst, which reduces the silicon-tethered aliphatic iodide to an alkyl radical to initiate 1,n-hydrogen atom transfer. Unactivated secondary and tertiary C-H bonds at beta, gamma, and delta positions can be functionalized in a predictable manner.
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