4.7 Article

Prevalence of Immunoglobulin G (IgG) Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Evaluation of a Rapid MEDsan IgG Test in Children Seeking Medical Care

Journal

CLINICAL INFECTIOUS DISEASES
Volume 72, Issue 7, Pages E192-E195

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciaa1702

Keywords

COVID-19; pediatrics; seroprevalence; rapid diagnostic test; antibody

Funding

  1. Department of Woman, Child and Adolescent Medicine
  2. Department of Diagnostics, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.

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In a study of 208 children seeking medical care, the seropositivity rate of anti-SARS-CoV-2 IgG antibodies was 8.7%, suggesting a similar infection rate to that of adults but greater than the incidence of RT-PCR-confirmed pediatric cases by over 100-fold. The MEDsan IgG rapid diagnostic test demonstrated accurate performance compared to the gold-standard combined ELISA + immunofluorescence.
In 208 children seeking medical care, the seropositivity rate of anti-SARS-CoV-2 IgG antibodies was 8.7%, suggesting an infection rate similar to that observed in adults but >100-fold the incidence of RT-PCR-confirmed pediatric cases. Compared with the gold-standard combined ELISA + immunofluorescence, the MEDsan IgG rapid diagnostic test performed accurately.

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