Journal
NEW JOURNAL OF CHEMISTRY
Volume 45, Issue 19, Pages 8445-8448Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nj06283a
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Funding
- DST-India [EMR/2017/000319]
- CSIR [02(0254)/16/EMR-II]
- DAE [201804BRE02 RP04978-BRNS]
- CSIR, New Delhi, India
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The stereoselective synthesis of 3,3'-disubstituted oxindoles with all-carbon quaternary stereocenters using KOH as a base has been achieved with an excellent diastereomeric ratio of 98:2. The practicality of the methodology has been demonstrated through the synthesis of a series of substrates with good to excellent yields. The aesthetic simplicity, accessibility, and eco-friendly nature of the base (KOH) have led to the broader application of this methodology in organic synthesis.
The stereoselective synthesis of 3,3 '-disubstituted oxindoles having all-carbon quaternary stereocenters has been achieved using KOH as a base with an excellent diastereomeric ratio (98 : 2). The practicability of the present methodology has been validated with the synthesis of a series of substrates in good to excellent yields. The aesthetic simplicity, accessibility, and eco-friendly base (KOH) have prompted the broader application of the present methodology in organic synthesis.
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