Journal
BIOENGINEERED
Volume 12, Issue 1, Pages 1916-1926Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21655979.2021.1927545
Keywords
Asthma; miR-146a-5p; traf6; inflammation; cell barrier injury; apoptosis
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This study found that miR-146a-5p expression is inhibited in asthma patients, but up-regulation can alleviate PAF-induced inflammatory reaction and damage in airway epithelial cells, possibly through negatively regulating TRAF6 expression.
Bronchial asthma is a common respiratory disease, which is characterized by airway inflammation, remodeling and hyperresponsiveness. MicroRNAs (miRNAs), as reported, are implicated in the pathogenesis of many diseases, but how miRNAs-146a-5p (miR-146a-5p) works in asthma remains inconclusive. In this work, we proved that miR-146a-5p expression was inhibited in asthma patients' plasma and platelet activating factor (PAF)-induced human small airway epithelial cells (HSAECs). MiR-146a-5p up-regulation ameliorated the inflammatory reaction and cell barrier damage of HSAECs induced by PAF, and inhibited the apoptosis; besides, miR-146a-5p down-regulation functioned oppositely. In addition, miR-146a-5p could target TNF receptor-associated factor 6 (TRAF6) and negatively regulate its expression. TRAF6 overexpression could counterract the impact of miR-146a-5p up-regulation on PAF-induced inflammation, cell barrier damage and apoptosis of HSAECs. Collectively, miR-146a-5p may protect airway epithelial cells and inhibit the pathogenesis of asthma via targeting TRAF6.
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