Journal
NEW JOURNAL OF CHEMISTRY
Volume 45, Issue 22, Pages 9995-10001Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1nj02117f
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Funding
- CNRS
- Universite Cote d'Azur (UCA, Nice)
- UM6P
- Moonshot D2M project
- BOF
- Research Foundation-Flanders (FWO) [11I6921N]
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A simple and eco-friendly method for synthesizing gold-NHC complexes bearing different thiosugars was reported. The obtained complexes showed strong cytotoxic activities against selected cancer cell lines.
A simple and eco-friendly route to gold-NHC complexes bearing different thiosugars is reported. The reaction between [Au(NHC)Cl] precursors, the thiosugars and a weak base proceeds under air using technical grade acetone under mild conditions (60 degrees C, 1 h). The one-pot synthesis of the same complexes starting from the corresponding imidazolium salts was also investigated. The obtained complexes showed strong cytotoxic activities against selected cancer cell lines with IC50 values in the submicromolar to low micromolar concentration range.
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