Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 8, Issue 14, Pages 3752-3759Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qo00398d
Keywords
-
Categories
Funding
- Natural Science Foundation of Shanxi Province [201601D011028]
- Key Research and Development Project of Shanxi Province [201903D321100]
Ask authors/readers for more resources
The study demonstrates that the in situ formation of N-aryl nitrones from the reaction of N-alkyl nitrones and nitrosoarenes is a key step. The protocol has a broad substrate scope and shows good selectivity and yields for most substrates.
N-Alkyl nitrones are used as the starting materials to construct various N-aryl isoxazolidines, instead of N-alkyl isoxazolidines or N-H 1,3-oxazinanes via a catalyst-free one-pot three-component reaction with nitroso compounds and olefins. The mechanism investigations indicate that the in situ formation of N-aryl nitrones from the reaction of N-alkyl nitrones and nitrosoarenes is the key step. The protocol features broad substrate scope, good to excellent chemo-, regio- and diastereo-selectivities, and moderate to excellent yields for most substrates.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available