Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 47, Pages 5838-5841Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc01411k
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Funding
- National Natural Science Foundation of China [21535004, 91753111, 21405097, 21390411, 21475079]
- Key Research and Development Program of Shandong Province [2018YFJH0502]
- Natural Science Foundation of Shandong Province [ZR201910220210]
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The research team synthesized a highly sensitive probe named TP-Golgi, which can quantitatively detect environmental polarity. Application of TP-Golgi in the kidneys of mice with AKI revealed a significant increase in Golgi polarity.
We synthesized an ultrasensitive probe TP-Golgi for the two-photon ratiometric fluorescence imaging of Golgi polarity. Probe TP-Golgi possesses a large Stokes shift, excellent sensitivity and good selectivity to quantitatively detect environmental polarity. By application of TP-Golgi, we found that the Golgi polarity increased obviously in the kidneys of mice with AKI.
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