Journal
NATURAL PRODUCT REPORTS
Volume 38, Issue 4, Pages 757-781Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0np00047g
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Funding
- Vienna Anniversary Foundation for Higher Education [H-268438/2018]
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This review discusses the research on retinoic acid receptor-related orphan receptors (RORs) from 1994 to 2020, focusing on natural ligands and indirect modulators of RORs and their potential therapeutic roles.
Covering: 1994 to 2020 Retinoic acid receptor-related orphan receptors (RORs) belong to a subfamily of the nuclear receptor superfamily and possess prominent roles in circadian rhythm, metabolism, inflammation, and cancer. They have been subject of research for over two decades and represent attractive but challenging drug targets. Natural products were among the first identified ligands of RORs and continue to be of interest to this day. This review focuses on ligands and indirect modulators of RORs from natural sources and explores their roles in a therapeutic context.
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