Iron-catalyzed domino decarboxylation-oxidation of α,β-unsaturated carboxylic acids enabled aldehyde C-H methylation

A practical and general iron-catalyzed domino decarboxylation-oxidation of alpha,beta-unsaturated carboxylic acids enabling aldehyde C-H methylation for the synthesis of methyl ketones has been developed. This mild, operationally simple method uses ambient air as the sole oxidant and tolerates sensitive functional groups for the late-stage functionalization of complex natural-product-derived and polyfunctionalized molecules.

Automated summary

A practical iron-catalyzed domino decarboxylation-oxidation reaction has been developed for the synthesis of methyl ketones from alpha,beta-unsaturated carboxylic acids. This method is mild, operationally simple, uses ambient air as the sole oxidant, and tolerates sensitive functional groups for late-stage functionalization of complex molecules.