Journal
JACC-BASIC TO TRANSLATIONAL SCIENCE
Volume 6, Issue 4, Pages 350-361Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacbts.2021.01.003
Keywords
biomaterials; chronic inflammation; chronic myocardial infarction; gene expression
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Funding
- National Institutes of Health National Heart, Lung, and Blood Institute (NHLBI) [R01HL113468]
- National Institutes of Health (NIH), NHLBI Training Grant [T32HL105373]
- NIH, NHLBI pre-doctoral fellowships [F31HL152686, F31HL137347]
- American Heart Association pre-doctoral fellowship
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The myocardial matrix hydrogel shows potential efficacy in chronic myocardial infarction patients by mitigating negative left ventricular remodeling through modulation of the immune response, down-regulation of pathways involved in heart failure progression and fibrosis, and up-regulation of genes important for cardiac muscle contraction.
A first-in-man clinical study on a myocardial-derived decellularized extracellular matrix hydrogel suggested the potential for efficacy in chronic myocardial infarction (MI) patients. However, little is understood about the mechanism of action in chronic MI. In this study, the authors investigated the efficacy and mechanism by which the myocardial matrix hydrogel can mitigate negative left ventricular (LV) remodeling in a rat chronic MI model. Assessment of cardiac function via magnetic resonance imaging demonstrated preservation of LV volumes and apical wall thickening. Differential gene expression analyses showed the matrix is able to prevent further negative LV remodeling in the chronic MI model through modulation of the immune response, down-regulation of pathways involved in heart failure progression and fibrosis, and up-regulation of genes important for cardiac muscle contraction. (C) 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
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