Journal
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
Volume 10, Issue 3, Pages 367-369Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jpids/piaa108
Keywords
disseminated gonococcal infection; metagenomics; next-generation sequencing
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DGI, a severe stage of gonorrhea infection, can be difficult to diagnose due to the limited sensitivity of current diagnostic tests. This study successfully detected Neisseria gonorrhoeae using metagenomic next-generation sequencing in joint aspirates of patients clinically diagnosed with DGI.
Disseminated gonococcal infection (DGI) often manifests as gonococcal arthritis and may carry significant morbidity. However, diagnosis remains elusive due to limited sensitivity of available diagnostic tests. We used metagenomic next-generation sequencing to detect Neisseria gonorrhoeae from culture-negative joint aspirates of 2 patients with clinically diagnosed DGI.
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