Journal
MEDICAL GAS RESEARCH
Volume 11, Issue 3, Pages 114-120Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/2045-9912.314331
Keywords
anti-autophagy; anti-inflammation; anti-oxidation; experimental research; hydrogen; neuroprotection; therapeutic applications; traumatic brain injury; underlying mechanism
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Funding
- Scientific Research of Jiangsu Commission of Health of China [H2018065]
- Scientific Research of Guizhou Commission of Health of China [gzwjkj2019-1-150]
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Traumatic brain injury (TBI) is a serious global public health problem, with survivors often facing long-term disabilities that burden society and families. Hydrogen, as a reducing gas, has shown neuroprotective effects in various cerebral diseases, but its efficacy in TBI remains controversial.
Traumatic brain injury (TBI) is a serious global public health problem. Survivors of TBI often suffer from long-term disability, which puts a heavy burden on society and families. Unfortunately, up to now, there is no efficacious treatment for TBI patients in clinical practice. As a reducing gas, hydrogen has been shown to be neuroprotective in multiple cerebral disease models; however, its efficacy in TBI remains controversial. In this review, we will focus on the results of hydrogen in experimental TBI, elaborate the potential mechanisms, and put forward for future researches based on our current understanding and views.
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