Journal
IMMUNE NETWORK
Volume 21, Issue 2, Pages -Publisher
KOREA ASSOC IMMUNOLOGISTS
DOI: 10.4110/in.2021.21.e17
Keywords
Abdominal aortic aneurysm; Gamma Delta T cells; IL-17A
Categories
Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [NRF-2020R1C1C1006210, NRF2019R1A2C2005176]
- Severance Hospital Research fund for Clinical excellence (SHRC) [C-2020-0038]
Ask authors/readers for more resources
The research found that V delta 2(+) T cells are presented at a higher frequency in aortic aneurysmal tissue compared to normal aortic tissue. In addition, these V delta 2(+) T cells in AAA tissue display immunophenotypes indicative of CCR5(+) non-exhausted effector memory cells, with a decreased proportion of CD16(+) cells. Furthermore, the study suggests that increased V delta 2(+) T cells producing IL-17A in aortic aneurysmal tissue may play a role in AAA pathogenesis and progression.
Abdominal aortic aneurysm (AAA) is a chronic dilation of the aorta with a tendency to enlarge and eventually rupture, which constitutes a major cause of cardiovascular mortality. Although T-cell infiltrates have been observed in AAA, the cellular, phenotypic,and functional characteristics of these tissue-infiltrating T cells are not fully understood. Here, we investigated the proportional changes of T-cell subsets-including CD4(+) T cells, CD8(+) T cells, and gamma delta T cells-and their effector functions in AAAs. We found that V delta 2(+) T cells were presented at a higher frequency in aortic aneurysmal tissue compared to normal aortic tissue and PBMCs from patients with AAA. In contrast, no differences were observed in the frequencies of CD4(+), CD8(+), and V delta 1(+) T cells. Moreover, we observed that the V delta 2(+) T cells from AAA tissue displayed immunophenotypes indicative of CCR5(+) non-exhausted effector memory cells, with a decreased proportion of CD16(+) cells. Finally, we found that these V delta 2(+) T cells were the main source of IL-17A in abdominal aortic aneurysmal tissue. In conclusion, our results suggest that increased V delta 2(+) T cells that robustly produce IL-17A in aortic aneurysmal tissue may contribute to AAA pathogenesis and progression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available