The role of tumor-associated macrophages in primary hepatocellular carcinoma and its related targeting therapy

Liver macrophages consist of ontogenically distinct populations termed Kupffer cells and monocyte-derived macrophages. Tumor-associated macrophages (TAMs) inhepatocellularcarcinoma (HCC) play a prominent role in tumormicroenvironment by presenting M1(induced by IFN gamma along with LPS) and M2(induced by IL-4 and IL13) polarization. Although TAMs are involved in tumor immune surveillance during the course of HCC, they contribute to tumour progression at different levels by inhibiting the anti-tumor immune response, promoting the generation of blood vessels and lymphatic vessels, and supporting the proliferation and survival of tumor cells. In this paper, the multiple functions of TAMs in HCC were reviewed to provide assistance for future researches about therapeutic approaches.

Automated summary

Liver macrophages, consisting of Kupffer cells and monocyte-derived macrophages, play a significant role in hepatocellular carcinoma through M1 and M2 polarization. While involved in tumor immune surveillance, TAMs in HCC also contribute to tumor progression by inhibiting anti-tumor immune response and supporting tumor cell proliferation. Understanding the diverse functions of TAMs can provide insights for future therapeutic approaches.