4.6 Article

Dual color triads: synthesis, photophysics and applications in live cell imaging

Journal

NEW JOURNAL OF CHEMISTRY
Volume 45, Issue 22, Pages 9984-9994

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1nj00900a

Keywords

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Funding

  1. GTU [2016-A-04, 2017-A105-31]

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This study introduces a novel triad system comprising subphthalocyanine, BODIPY, and thiophene/thianaphthene units, with optical properties analyzed through various spectroscopic methods and evaluation in breast cancer cell imaging. The triads showed dual color emission, demonstrating significance in biomedical applications.
Fluorescent labels and probes constitute an important class of organic materials used in the development of sensor systems and imaging platforms for various chemical and molecular biology applications. In the development of fluorescent labels and probes, multichromic environment-sensitive fluorophores are very important. In this work, novel triad systems, including subphthalocyanine, BODIPY and thiophene/thianaphthene units, were prepared and their molecular structures were identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and H-1 and C-13 NMR spectroscopy. The optical properties of the subphthalocyanine-BODIPY-thiophene/thianaphthene triads were determined using UV-vis absorption and fluorescence (2D and 3D) spectroscopic methods and quantum chemical calculations. The data were analyzed by comparing the results of the final properties to those of the BODIPY- and subphthalocyanine-alone units. The compounds were also evaluated in live cell imaging using a breast cancer cell line. The novel subphthalocyanine-BODIPY-thiophene/thianaphthene triads displayed dual color emission, which is critically important for the development of novel systems particularly in biomedical applications such as bioimaging and cellular sensor systems.

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