Journal
FETAL AND PEDIATRIC PATHOLOGY
Volume 36, Issue 3, Pages 232-239Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15513815.2017.1303860
Keywords
Oxidative stress; small for gestational age; cesarean section; superoxide dismutase; malondialdehyde
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Funding
- Acibadem University Maslak Hospital
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Introduction: The aim of our study was to determine lipid peroxidation products and antioxidant enzyme activity in umbilical cord blood of small for gestational age (SGA) neonates. Materials and methods: Umbilical cord arterial blood samples were collected from 21-term singleton SGA newborn infants and 21 age- and sex-matched appropriate for gestational age (AGA) term neonates prospectively born by elective cesarean section for determination of malondialdehyde (MDA) as a marker of lipid peroxidation and superoxide dismutase (SOD) for antioxidant activity. Results: MDA levels were increased (5.20vs. 3.52 nmol/mL; p < 0.001), while levels of SOD (6.24vs. 8.99 U/mL; p < 0.01) were decreased in SGA neonates when compared with AGA newborn infants. Conclusions: Elevated MDA levels and decreased SOD activity in umbilical cord blood may show the possibility of insufficient protective mechanisms against increased oxidative stress in SGA neonates born by cesarean section.
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