Journal
FERTILITY AND STERILITY
Volume 107, Issue 1, Pages 198-204Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2016.09.041
Keywords
Cancer; fertility preservation; in vitro maturation; luteal phase
Categories
Ask authors/readers for more resources
Objective: To evaluate the feasibility and the efficacy of in vitro maturation (IVM) when immature oocyte collection was performed in the early follicular, late follicular, or luteal phases in women with cancer who require urgent chemotherapy. Design: Retrospective cohort study. Setting: University teaching hospital. Patient(s): One-hundred and sixty-four women with cancer undergoing IVM treatment for fertility preservation. Intervention(s): Oocyte retrieval, IVM, cryopreservation. Main Outcome Measure(s): Medians (interquartile range) of oocytes collected, maturation rates after 48 hours of culture, and metaphase II oocytes cryopreserved. Result(s): The analysis included a total of 192 cycles grouped into early follicular phase (n = 46), late follicular phase (n = 107), or luteal phase (n = 39). Embryo cryopreservation was performed in 82 cycles, and oocyte cryopreservation in 105 cycles. Between the early follicular, late follicular, and luteal phases, no statistically significant differences were found in the number of oocytes collected (8.5 [4-15.8], 8 [5-14], and 7 [4-9], respectively), the maturation rates after 48 hours of culture (53.5% [39.8-77], 58% [44-82], and 50% [33-67], respectively), or the number of oocytes cryopreserved (3 [0-7.3], 3 [0-7], and 3 [1-5.5], respectively). Similarly, the fertilization rates (77 [62.8-92.5], 75 [60-100], and 63.5 [50-75], respectively) and number of embryos cryopreserved (3 [2-5.8], 3 [0.5-5], and 2 [13], respectively) were not statistically significantly different among the groups. Conclusion(s): Our study confirms the feasibility of IVM collection at any time during the menstrual cycle. Treatment with IVM is an alternative method when chemotherapy cannot be delayed or ovarian stimulation is contraindicated. The long-term outcomes remain to be studied. (C) 2016 by American Society for Reproductive Medicine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available