Journal
NEW JOURNAL OF CHEMISTRY
Volume 45, Issue 23, Pages 10296-10302Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1nj01272j
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Funding
- National Natural Science Foundation of China [62075013]
- Guangdong Provincial Key Laboratory of Biomedical Optical Imaging Technology [020B121201010]
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The study utilizes Cu2O-MoS2 nanomaterial to combine CDT and PTT, attacking tumor cells through enhanced Fenton-like reaction and photothermal effects, demonstrating promising therapeutic potential.
Chemodynamic therapy (CDT) with selective therapeutic and minimal side effects has attracted increasing attention in recent years. Nevertheless, the limited H2O2 and acid contents in the tumor microenvironment suppress the efficiency of the Fenton reaction. To overcome these issues, photothermal therapy (PTT) is employed to amplify the CDT effect and realize synergistic PTT/CDT. Herein, MoS2 sheets are functionalized with copper (Cu2O-MoS2), which integrates enhanced CDT and PTT to combat tumor cells. The 808 nm light activated Cu2O-MoS2 nanoplatform appears to be a potential candidate to improve the synergistic effect on the enhanced Fenton-like reaction and photothermal performance.
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