Journal
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume 36, Issue 18, Pages -Publisher
KOREAN ACAD MEDICAL SCIENCES
DOI: 10.3346/jkms.2021.36.e124
Keywords
SARS-CoV-2; COVID-19; Spike Protein; Mutation; Variant; Vaccine
Categories
Funding
- National Natural Science Foundation of China [81801643]
- Beijing Municipal Science and Technology Commission [19L2152]
- Chinese PLA General Hospital [QNC19047]
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SARS-CoV-2 has caused a global pandemic since its discovery, leading to the emergence of variants with common N501Y mutations that may impact viral fitness and transmission, although the effects on COVID-19 vaccines remain unknown.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which has spread worldwide since it was first identified in Wuhan, China, at the end of 2019. With the global transmission of the virus, a large number of SARS-CoV-2 variants have also appeared, especially, emerging strains that have recently been discovered in the United Kingdom (variant 20I/501Y.V1, lineage B.1.1.7), South Africa (variant 20H/501Y.V2, lineage B.1.351), and Brazil (variant 20 J/501Y.V3, and lineage P.1). The common feature of these variants is that they share the N501Y mutation involving the SARS-CoV-2 spike (S) protein, which is precisely the target of most COVID-19 vaccines. Furthermore, mutations such as N501Y, E484K, and K417N in the S protein may affect viral fitness and transmissibility. However, current research on the impact of these variants on COVID-19 vaccines is still lacking. Herein, we briefly explain why most COVID-19 vaccines target the S protein, update the progress of research regarding S protein-related COVID-19 vaccines, review the latest studies concerning the effects of S protein variants on COVID-19 vaccines, and finally, propose certain strategies to deal with SARS- CoV-2 variants.
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