Four-component synthesis of 3-aminomethylated imidazoheterocycles in EtOH under catalyst-free, oxidant-free and mild conditions

With green ethanol as the sole solvent, various 3-aminomethylated imidazoheterocycles were efficiently synthesized in one step through a four-component reaction of equimolar cheap and commercially available reactants at ambient temperature under metal-free, oxidant-free and mild conditions.

Automated summary

This study efficiently synthesized various 3-aminomethylated imidazoheterocycles in one step using green ethanol as the sole solvent, under metal-free, oxidant-free, and mild conditions with cheap and commercially available reactants.