Journal
GREEN CHEMISTRY
Volume 23, Issue 12, Pages 4375-4385Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1gc00742d
Keywords
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Funding
- Draper Technology Innovation Fund
- Graduate School at the University of Wisconsin-Madison
- Office for Therapeutic Discovery and Development at the Institute for Clinical and Translational Research - Clinical and Translational Science Award (CTA) program, the National Center for Advancing Translational Sciences (NCATS) [1UL1TR002373]
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Ionic liquids (ILs) are considered as a green alternative to traditional materials, but some hydrophobic ILs (HILs) have been found to be toxic. This study aims to diversify HILs by synthesizing two sets of HILs with unique cations and anions, totaling twenty different HILs. Each HIL is characterized using traditional physicochemical techniques and evaluated for toxicity using both in vitro and in vivo methods.
Ionic liquids (ILs) have been labeled as a promising green alternative to traditional materials; however, many ILs have been discovered to be toxic, especially hydrophobic ILs (HILs). HILs are limited in their structural diversity as most are composed of heteroaromatic cations with long alkyl chains and paired with [BF4], [PF6], or [NTf2] anions. This study aims to diversify HILs by synthesizing two sets of HILs with unique cations and anions. The first set of HILs contain cholinium- and dicholinium-based cations paired with the [NTf2] anion. The [DC-ether] cation is identified as a promising cation and is paired with an array of asymmetric bis(sulfonyl)amide anions to form the second set of HILs. In total, twenty HILs are synthesized. Each HIL is characterized using traditional physicochemical techniques and is evaluted for toxicity using in vitro and in vivo methods.
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