4.7 Article

Photo-initiated enhanced antibacterial therapy using a non-covalent functionalized graphene oxide nanoplatform

Journal

DALTON TRANSACTIONS
Volume 50, Issue 24, Pages 8404-8412

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1dt00642h

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Funding

  1. National Natural Science Foundation of China [51703259]

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This study introduces a novel antibacterial phototherapeutic platform using a zinc tetraaminophthalocyanine-modified graphene oxide nanocomposite, which efficiently heals bacteria-infected wounds through both photodynamic and physical actions. The nanocomposite can kill Gram-positive and Gram-negative bacteria by generating reactive oxygen species and physically cutting bacterial cell membranes.
This study describes a novel antibacterial phototherapeutic platform for highly efficient healing of bacteria-infected wounds. It is based on the photodynamic and physical actions of a zinc tetraaminophthalocyanine-modified graphene oxide nanocomposite produced via non-covalent functionalization. The nanocomposite is positively charged and can easily capture negatively charged bacteria via electrostatic interactions. The antibacterial action is two-fold: (1) reactive oxygen species are produced by the phthalocyanine photosensitizer after short-term exposure to 680 nm light and (2) the graphene oxide can physically cut bacterial cell membranes. These enhanced activities can kill Gram-positive and Gram-negative bacteria at very low dosages. An ultrastructural examination indicates that this nanocomposite causes enormous damage to bacterial morphology and leakage of intracellular substances that lead to bacterial death. A rat wound model is used to demonstrate that the proposed phototherapeutic platform has low cytotoxicity and can promote rapid healing in bacteria-infected wounds. These results suggest that the integration of different antibacterial methods into a single nanotherapeutic platform is a promising strategy for anti-infective treatment.

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