Journal
MEDICINA-LITHUANIA
Volume 57, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/medicina57050423
Keywords
granulomatosis with polyangiits; wegener’ s granulomatosis; subglottic stenosis; steroid; rituximab
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Severe subglottic stenosis in GPA requires active intratracheal intervention, surgery, and systemic immunosuppressive therapy for treatment.
Granulomatosis with polyangiitis (GPA) is an autoimmune disease characterized by necrotizing granulomatous inflammation. Subglottic stenosis, which is defined as narrowing of the airway below the vocal cords, has a frequency of 16-23% in GPA. Herein, we present the case of a 39-year-old woman with subglottic stenosis manifesting as life-threatening GPA, which was recurrent under systemic immunosuppressive therapy. The patient underwent an emergency tracheostomy, intratracheal intervention, such as carbon dioxide (CO2) laser surgery and intralesional steroid injection via laryngomicroscopic surgery, and laryngotracheal resection with remodeling. Severe subglottic stenosis treatment requires active intratracheal intervention, surgery, and systemic immunosuppressive therapy.
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