Journal
JOURNAL OF CANCER
Volume 12, Issue 12, Pages 3686-3700Publisher
IVYSPRING INT PUBL
DOI: 10.7150/jca.57776
Keywords
anticancer; phytochemicals; healthcare economy; targeted prevention; bioavailability
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Phytochemicals show great potential in cancer treatment and can reduce the side-effects of chemotherapy. By interfering with cell signaling pathways, these biologically active compounds effectively inhibit the growth of cancer cells and protect healthy cells from damage.
Cancer is one of the leading causes of death across the world. Although conventional cancer treatments such as chemotherapy and radiotherapy have effectively decreased cancer progression, they come with many dose-limiting side-effects. Phytochemicals that naturally occur in spices, fruits, vegetables, grains, legumes, and other common foods are surprisingly effective complements to conventional cancer treatments. These biologically active compounds demonstrate anticancer effects via cell signaling pathway interference in cancerous cells. In addition, phytochemicals protect non-cancerous cells from chemotherapy-induced side-effects. This paper addresses the not only the potential of phytochemicals quercetin, isoflavones, curcumin, catechins, and hesperidin in terms of cancer treatment and protection against side-effects of chemotherapy, but also methods for increasing phytochemical bioavailability.
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