Journal
DISEASES
Volume 9, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/diseases9020030
Keywords
mitochondrial dysfunction; cytokine storm; melatonin; micronutrients; vitamins; minerals; oxidative-inflammatory disorders; COVID-19
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Funding
- Research and Technology Council of Cuyo University (SECyT), Mendoza, Argentina
- National Agency for the Promotion of Research, Technological Development and Innovation ANPCyT FONCyT [PICT 2016-4541]
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Exaggerated oxidative stress and hyper-inflammation are essential features of oxidative/inflammatory diseases and may be related to mitochondrial dysfunction. Natural substances such as melatonin and micronutrients can prevent or reduce mitochondrial damage, preserving a state of health.
Exaggerated oxidative stress and hyper-inflammation are essential features of oxidative/inflammatory diseases. Simultaneously, both processes may be the cause or consequence of mitochondrial dysfunction, thus establishing a vicious cycle among these three factors. However, several natural substances, including melatonin and micronutrients, may prevent or attenuate mitochondrial damage and may preserve an optimal state of health by managing the general oxidative and inflammatory status. This review aims to describe the crucial role of mitochondria in the development and progression of multiple diseases as well as the close relationship among mitochondrial dysfunction, oxidative stress, and cytokine storm. Likewise, it attempts to summarize the main findings related to the powerful effects of melatonin and some micronutrients (vitamins and minerals), which may be useful (alone or in combination) as therapeutic agents in the treatment of several examples of oxidative/inflammatory pathologies, including sepsis, as well as cardiovascular, renal, neurodegenerative, and metabolic disorders.
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