Journal
MINERVA RESPIRATORY MEDICINE
Volume 60, Issue 2, Pages 52-58Publisher
EDIZIONI MINERVA MEDICA
DOI: 10.23736/S2784-8477.20.01895-7
Keywords
COVID-19; Middle East respiratory syndrome coronavirus; Severe acute respiratory syndrome; Neurologic manifestations
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COVID-19 primarily causes respiratory symptoms in patients, but can also lead to neurological symptoms. These neurological symptoms, classified into CNS and PNS presentations, require further research to understand the virus's impact on the brain and nervous system.
The novel coronavirus disease 2019 (COVID-19) is a causative agent of severe lower respiratory tract infection in patients. Since its discovery in December 2019, COVID-19 has spread to five continents and to this date, affected approximately 6,260,000 people. COVID-19 patients typically present with symptoms related to the respiratory system while neurological manifestations have scarcely been reported. Neurological presentations of COVID-19 infection are classified into two groups: CNS symptoms and peripheral nervous system (PNS) symptoms. CNS symptoms include headache, dizziness, loss of consciousness, convulsion, ataxia and acute cerebrovascular disease. The PNS symptoms consist of hypoplasia, hyposmia, hypogeusia and neuralgia. The association between COVID-19 and neurological problems needs further clarification and warrants detailed microbiological and pathological studies to better understand the virus and its impact on the brain and nervous system.
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