Journal
FEBS LETTERS
Volume 592, Issue 1, Pages 89-102Publisher
WILEY
DOI: 10.1002/1873-3468.12929
Keywords
Arabidopsis; MAP kinase; PIN; protein phosphorylation; signalling
Funding
- EC [ERG 256554]
- Hungarian Research Fund [OTKA K101250, NN114511, NN111085]
- GENPROF Research Infrastructure Grant of the Hungarian Academy of Sciences [IF-18/2012]
- UK BBSRC [BBSB13314, BB/M025047/1]
- Deutsche Forschungsgemeinschaft [SFB 746]
- Excellence Initiative of the German Federal Government [EXC 294]
- Excellence Initiative of the German State Government [EXC 294]
- Bundesministerium fur Forschung und Technik (BMBF SYSTEC, PROBIOPA)
- Deutsches Zentrum fur Luft und Raumfahrt [DLR 50WB1022]
- Freiburg Initiative for Systems Biology
- European Union [LSHG-CT-2007-037897]
- Biotechnology and Biological Sciences Research Council [BB/M025047/1] Funding Source: researchfish
- BBSRC [BB/M025047/1] Funding Source: UKRI
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Plant growth flexibly adapts to environmental conditions, implying cross-talk between environmental signalling and developmental regulation. Here, we show that the PIN auxin efflux carrier family possesses three highly conserved putative mitogen-activated protein kinase (MAPK) sites adjacent to the phosphorylation sites of the well-characterised AGC kinase PINOID, which regulates the polar localisation of PINs and directional auxin transport, thereby underpinning organ growth. The conserved sites of PIN1 are phosphorylated in vitro by two environmentally activated MAPKs, MPK4 and MPK6. In contrast to AGC kinases, MAPK-mediated phosphorylation of PIN1 at adjacent sites leads to a partial loss of the plasma membrane localisation of PIN1. MAPK-mediated modulation of PIN trafficking may participate in environmental adjustment of plant growth.
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