Journal
FEBS LETTERS
Volume 591, Issue 7, Pages 991-1000Publisher
WILEY
DOI: 10.1002/1873-3468.12608
Keywords
apoptosis; ceRNET; CYP4Z1; CYP4Z2P; hTERT
Funding
- National Major Special Program of New Drug Research and Development [2013ZX09301303-005]
- National Natural Science Foundation of China [81372331]
- Fundamental Research Funds for the Central Universities [2015ZD004]
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
- Qing Lan Project
- Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP)
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The competing endogenous RNA network (ceRNET) is involved in tumorigenesis and has become a hot spot of research. The ceRNET between CYP4Z1 and the pseudogene CYP4Z2P promotes angiogenesis and mediates tamoxifen resistance in breast cancer. Nevertheless, the effects of this ceRNET on cell apoptosis and related mechanisms remain unclear. In the present study, we found that downregulation of CYP4Z1 or the CYP4Z2P 3 '-UTR promotes cell apoptosis, mirroring the functions of human telomerase reverse transcriptase (hTERT). Furthermore, the ceRNET between CYP4Z1 and pseudogene CYP4Z2P modulates hTERT expression by operating as a sub-ceRNET for hTERT. Our data demonstrate that the ceRNET between CYP4Z1 and pseudogene CYP4Z2P acts as a sub-ceRNET for hTERT and, thus, inhibits breast cancer apoptosis.
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