Journal
FEBS LETTERS
Volume 591, Issue 18, Pages 2890-2904Publisher
WILEY
DOI: 10.1002/1873-3468.12795
Keywords
ADAR; breast cancer; Ctn RNA; HuR; mRNA stability; RNA editing
Funding
- National Institute of Health [1RO1GM088252, 1RO1GM099669]
- American Cancer Society [RSG-11-174-01-RMC]
- National Science Foundation [1243372]
- EAGER
- National Institute on Aging-Intramural Research Program
- National Institutes of Health [Z01AG000511]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1243372] Funding Source: National Science Foundation
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Adenosine deaminases acting on RNA (ADARs) are proteins that catalyse widespread A-to-I editing within RNA sequences. We recently reported that ADAR2 edits and stabilizes nuclear-retained Cat2 transcribed nuclear RNA (Ctn RNA). Here, we report that ADAR1 coordinates with ADAR2 to regulate editing and stability of Ctn RNA. We observe an RNA-dependent interaction between ADAR1 and ADAR2. Furthermore, ADAR1 negatively regulates interaction of Ctn RNA with RNA-destabilizing proteins. We also show that breast cancer (BC) cells display elevated ADAR1 but not ADAR2 levels, compared to nontumourigenic cells. Additionally, BC patients with elevated levels of ADAR1 show low survival. Our findings provide insights into overlapping substrate preferences of ADARs and potential involvement of ADAR1 in BC.
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