Journal
FEBS LETTERS
Volume 591, Issue 2, Pages 382-392Publisher
WILEY
DOI: 10.1002/1873-3468.12538
Keywords
breast cancer; endocrine resistance; estrogen receptor; isoform; microRNA; miRNA-335
Funding
- National Institutes of Health [CA125806, CA174785]
- Office of Naval Research [N00014-16-1-1136]
- National Center for Research Resources [P20RR020152]
- Department of Defense Breast Cancer Research Program [BC085426, NCI-U54 CA113001-07]
- National Institute of General Medical Sciences of the National Institutes of Health [U54 GM104940]
- NATIONAL CANCER INSTITUTE [R01CA174785, U54CA113001, R01CA125806] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR020152] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [U54GM104940] Funding Source: NIH RePORTER
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microRNAs (miRNAs) are small noncoding RNA molecules involved in the regulation of gene expression and play critical roles in human malignancies. Next-generation sequencing analysis of the MCF-7 breast cancer cell line overexpressing miR-335-5p and miR-335-3p demonstrated that the miRNA duplex repressed genes involved in the ERa signaling pathway, and enhanced resistance of MCF-7 cells to the growth inhibitory effects of tamoxifen. These data suggest that despite its conventional role in tumor suppression, the miR-335 transcript can also play an oncogenic role in promoting agonistic estrogen signaling in a cancerous setting.
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