Journal
FEBS LETTERS
Volume 591, Issue 7, Pages 1041-1052Publisher
WILEY
DOI: 10.1002/1873-3468.12606
Keywords
carotid artery injury; miR-124; neointima; S100A4; vascular smooth muscle cell proliferation
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [2016R1A4A1009895, 2015R1A2A1A05001708]
- National Research Foundation of Korea grant - Korean government [2012-0005602]
- National Research Foundation of Korea grant (MRC) - Korea government (MSIP) [2011-0030132]
- National Research Foundation of Korea [2015R1A2A1A05001708] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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S100 calcium-binding protein A4 (S100A4) induces proliferation and migration of vascular smooth muscle cells (VSMCs). We aimed to find the microRNA regulating S100A4 expression. S100A4 transcripts are abruptly increased in the acute phase of carotid arterial injury 1 day later (at day 1) but gradually decreases at days 7 and 14. Bioinformatics analysis reveals that miR-124 targets S100A4. VSMC survival is attenuated by miR-124 mimic but increased by miR-124 inhibitor. miR-124 decreases immediately after carotid arterial injury but dramatically increases at days 7 and 14. miR-124 inhibitor-induced cell proliferation is blocked by S100A4 siRNA, whereas miR-124-induced cell death is recovered by S100A4. Our findings suggest that miR-124 is a novel regulator of VSMC proliferation and may play a role in the development of neointimal proliferation.
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