Journal
RSC ADVANCES
Volume 11, Issue 25, Pages 15290-15295Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ra10868e
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Funding
- Guizhou Provincial Department of Education Foundation [QJHKY2020-067]
- National Natural Science Foundation of China [21502049, 22062022]
- Foundation of the Department of Education of Guizhou Province [KY[2018]030]
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A selective and mild method for the synthesis of N-aryl amides was developed in this study, with good yields obtained in water from commercially available nitroarenes and acyl halides. The reaction, with Fe dust as the only reductant and additive, can be easily performed on a large scale.
Amides are prevalent in nature and valuable functional compounds in agrochemical, pharmaceutical, and materials industries. In this work, we developed a selective and mild method for the synthesis of N-aryl amides. Starting from commercially available nitroarenes and acyl halides, N-aryl amides with good yields can be obtained in water. Especially in the process of transformation, Fe dust is the only reductant and additive, and the reaction can be easily performed on a large scale.
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