SNHG7 HAS AN ONCOGENIC ROLE IN COLORECTAL CANCER VIA POTENTIAL SPONGING OF MIR-485-5P AND MIR-193A-5P; IN SILICO APPROACH

SNHG7, as a member of the small nucleolar host gene family, is a recently identified long non-coding RNA (lncRNA). Different reports have identified the SNHGs as competing endogenous RNAs (ceRNAs) sponging miRNAs with a role in cancer progression. However, the biological functions of SNHG7 in the colorectal cancer (CRC) remained to be almost unknown. The current in silico study was aimed to find the potential role of SNHG7 in the CRC development. In this study, we showed the up-regulation of SNHG7 as well as its potential correlation with miRNAs, including mir -193a-5p and mir-485-5P. We hypothesized that SNHG7 modulates these miRNAs availability by acting as a molecular sponge. Our findings showed the potential targets of these miRNAs by studying different databases as well as in silico analyses. In summary, we found SNHG7 as a potential ceRNA which may be a promising biomarker for diagnostic and therapeutic target in CRC.

Automated summary

This study revealed the potential role of SNHG7 in colorectal cancer, suggesting its involvement in cancer progression by modulating the availability of miRNAs. By analyzing different databases and conducting in silico studies, potential targets of SNHG7 were identified. This indicates that SNHG7 may serve as a promising biomarker for diagnosis and treatment of colorectal cancer.