Journal
GAZI MEDICAL JOURNAL
Volume 32, Issue 2, Pages 231-234Publisher
GAZI UNIV, FAC MED
DOI: 10.12996/gmj.2021.52
Keywords
Bullous systemic lupus erythematosus; lupus nephritis; antinuclear antibody
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Bullous systemic lupus erythematosus (BSLE) is a rare autoimmune blistering condition that can present with generalized vesiculobullous skin eruptions, especially in children, and may be the initial manifestation of SLE. A high index of suspicion and the appropriate diagnostic tools are crucial in unmasking the true diagnosis.
Bullous systemic lupus erythematosus (BSLE) is a rare autoimmune blistering condition. A 10-year-old boy presented with generalized vesiculobullous skin eruptions and was initially diagnosed with bullous disease of childhood. Indirect immunofluorescence testing for antinuclear antibodies (ANA) was positive, with a homogeneous pattern and a titre of >= 1.:640. His skin biopsy revealed the presence of subepidermal bullae with linear deposition of IgG and C3 along the basement membrane. Renal biopsy showed class III lupus nephritis. Our case illustrates that bullous skin lesion can be the initial presentation of SLE especially in children. Thus, a high index of suspicion and the right diagnostic tools are crucial to unmask the true diagnosis.
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