Journal
DRUG DESIGN DEVELOPMENT AND THERAPY
Volume 15, Issue -, Pages 2269-2287Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/DDDT.S308578
Keywords
cytokine therapy; cancer immunity cycle; cancer immunotherapy; clinical trial; nanomedicine
Categories
Funding
- National Natural Science Foundation of China [31800006]
- Natural Science Foundation of Guangdong Province [2018A030313563]
- Guangzhou Basic and Applied Basic Research Foundation [202002030127]
- Guangdong Basic and Applied Basic Research Foundation [2021A1515012324]
- Fundamental Research Funds for the Central Universities [20ykzd08]
- Program for Guangdong Introducing Innovative and Entrepreneurial Teams [2016ZT06S252]
- Guangdong Financial Fund for High-Caliber Hospital Construction
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Cytokines play crucial roles in the immune response to cancer and hold promise for precise cancer treatment. Clinical studies have shown progress in the use of cytokine-based drugs for cancer therapy, focusing on improving delivery efficiency, stability, biocompatibility, and availability.
Cytokines are key components of the immune system and play pivotal roles in anticancer immune response. Cytokines as either therapeutic agents or targets hold clinical promise for cancer precise treatment. Here, we provide an overview of the various roles of cytokines in the cancer immunity cycle, with a particular focus on the clinical researches of cytokine-based drugs in cancer therapy. We review 27 cytokines in 2630 cancer clinical trials registered with ClinicalTrials.gov that had completed recruitment up to January 2021 while summarizing important cases for each cytokine. We also discuss recent progress in methods for improving the delivery efficiency, stability, biocompatibility, and availability of cytokines in therapeutic applications.
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