Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 51, Pages 6288-6291Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc01129d
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Funding
- Fundamental Research Funds for the National Natural Science Foundation of China [21804073]
- Natural Science Foundation of Zhejiang Province of China [LQ18B050002]
- Open Foundation of State Key Laboratory of Chemo/Biosensing and Chemometrics [2017014]
- Natural Science Foundation of Ningbo City [2018A610315, 2019A610195]
- Research Foundation Project of Ningbo University
- Research Startup Foundation of Ningbo University
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The dual-mode bio-imaging nanoprobe TP-CQDs@MnO2, utilizing two-photon carbon quantum dots and MnO2, is developed for two-photon fluorescence and MR imaging of endogenous H2O2 in the tumor microenvironment. It shows high selectivity, a great signal-to-noise ratio, a LOD of 1.425 pM for H2O2, and a two-photon tissue penetration depth of 280 μm.
The dual-mode bio-imaging nanoprobe TP-CQDs@MnO2, based on two-photon carbon quantum dots and MnO2, has been developed for the two-photon fluorescence and MR imaging of endogenous H2O2 in the tumor microenvironment, and it achieved high selectivity, a great signal-to-noise ratio, a limit of detection (LOD) of 1.425 pM for H2O2, and a two-photon tissue penetration depth of 280 mu m.
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