FUT8 and Protein Core Fucosylation in Tumours: From Diagnosis to Treatment

Glycosylation changes are key molecular events in tumorigenesis, progression and glycosyltransferases play a vital role in the this process. FUT8 belongs to the fucosyltransferase family and is the key enzyme involved in N-glycan core fucosylation. FUT8 and/or core fucosylated proteins are frequently upregulated in liver, lung, colorectal, pancreas, prostate,breast, oral cavity, oesophagus, and thyroid tumours, diffuse large B-cell lymphoma, ependymoma, medulloblastoma and glioblastoma multiforme and downregulated in gastric cancer. They can be used as markers of cancer diagnosis, occurrence, progression and prognosis. Core fucosylated EGFR, TGFBR, E-cadherin, PD1/PD-L1 and alpha 3 beta 1 integrin are potential targets for tumour therapy. In addition, IGg1 antibody defucosylation can improve antibody affinity, which is another aspect of FUT8 that could be applied to tumour therapy.

Automated summary

The research highlights the association between FUT8 and core fucosylation in various tumors, suggesting their potential as markers for cancer diagnosis and prognosis, as well as providing potential targets for tumor therapy. Additionally, defucosylation of IGg1 antibodies may enhance antibody affinity, presenting another avenue for tumor therapy utilizing FUT8.